86 lines
57 KiB
JSON
86 lines
57 KiB
JSON
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{
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"patient_firstname":"Rainer",
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"patient_lastname":"Zufall",
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"patient_dateofbirth":"19.06.1953",
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"patient_diagnosis_short":"",
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"mutation_load":"",
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"mutation_ns_snv":"5",
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"mutation_affected_oncogenes":"0",
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"mutation_affected_tumorsupressorgenes":"1",
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"mutation_additional_information":"",
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"mskdg":[
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{
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"Gene": "ARID1B",
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"Mutation": "p.Asp1747_Glu1749del",
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"Confidence": 3,
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"Type": "TSG",
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"References": "1,2,3"
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}
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],
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"ptp_da":[
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{
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"Gene": "SRMS",
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"Mutation": "p.Glu396Gln",
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"Therapy": "dasatinib",
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"Confidence": 1,
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"References": "4"
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}
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],
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"ptp_ia":[],
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"mskpe":[],
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"ref":[
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{
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"rowid": 1,
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"citation": "Futreal et al., A census of human cancer genes., Nature reviews. Cancer, 4, 3, 2004"
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},
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{
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"rowid": 2,
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"citation": "Vogelstein et al., Cancer genome landscapes., Science (New York, N.Y.), 339, 6127, 2013"
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},
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{
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"rowid": 3,
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"citation": "Rubio et al., In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities., Cancer cell, 27, 3, 2015"
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},
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{
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"rowid": 4,
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"citation": "Santos et al., A comprehensive map of molecular drug targets., Nature reviews. Drug discovery, 16, 1, 2017"
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}
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],
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"appendix":[
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{
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"Gene": "ZDHHC13",
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"Mutation": "p.Pro518LeufsTer7", "tumor_af": "0.41", "Variant": "frameshift", "Activation": "+",
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"dbSNP": [],
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"COSMIC": []
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},
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{
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"Gene": "SRMS",
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"Mutation": "p.Glu396Gln", "tumor_af": "0.39", "Variant": "missense", "Activation": "-",
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"dbSNP": [],
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"COSMIC": ["COSM339980"]
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},
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{
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"Gene": "ARID1B",
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"Mutation": "p.Asp1747_Glu1749del", "tumor_af": "0.35", "Variant": "missense", "Activation": "-",
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"dbSNP": [],
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"COSMIC": []
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},
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{
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"Gene": "CEP72",
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"Mutation": "p.Arg614Ile", "tumor_af": "0.3", "Variant": "stop gained", "Activation": "+",
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"dbSNP": [],
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"COSMIC": []
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},
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{
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"Gene": "OTOP2",
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"Mutation": "p.Glu191Lys", "tumor_af": "0.21", "Variant": "missense", "Activation": "+",
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"dbSNP": [],
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"COSMIC": ["COSM5387266"]
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}
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],
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"graphString":[
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{
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"data": "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}
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]
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}
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